{"id":457,"date":"2013-09-30T10:42:37","date_gmt":"2013-09-30T10:42:37","guid":{"rendered":"https:\/\/www.academy.einumm.org\/?page_id=457"},"modified":"2020-11-12T14:37:20","modified_gmt":"2020-11-12T13:37:20","slug":"150anni","status":"publish","type":"page","link":"https:\/\/academy.einumm.org\/it\/150anni\/","title":{"rendered":"Referenze Bibliografiche Libro &#8220;Come Vivere fino a 150 anni&#8221;"},"content":{"rendered":"\n<p class=\"has-text-align-center\"><strong><span style=\"font-size: 16px;\">Il libro &#8220;Come vivere 150 anni&#8221; del Dr. Tsoukalas fa riferimento a innumerevoli ricerche in ambito scientifico e medico.<\/span><\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><span style=\"font-size: 16px;\">Sarebbe stato impossibile includere nel libro tutti i riferimenti bibliografici a cui esso attinge.<\/span><\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong><span style=\"font-size: 16px;\">In questa pagina daremo alcuni approfondimenti sugli argomenti toccati nel volume e forniremo la vasta bibliografia associata.<\/span><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed-youtube wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<p class=\"responsive-video-wrap clr\"><iframe title=\"Cos&#039;\u00e8 la Metabolomica\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/URYRjswJYYY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<\/div><\/figure>\n\n\n\n<p><strong>Chapter 1<\/strong><\/p>\n\n\n\n<ul><li>Driver, Julia. \u201cThe History of Utilitarianism.\u201d Stanford Encyclopedia of Philosophy, Stanford University, 22 Sept. 2014<\/li><li>Guggenheim, E. A. Thermodynamics: an Advanced Treatment for Chemists and Physicists. North-Holland, 1993.<\/li><li>Rubi, Miguel J. \u201cDoes Nature Break the Second Law of Thermodynamics.\u201d Scinetific American, 2008, available at: www.scientificamerican.com\/article\/how-nature-breaks-the-second-law\/.<\/li><li>Edelstein, Ludwig. The Hippocratic Oath, Text, Translation and Interpretation by Ludwig Edelstein. Johns Hopkins Press, 1943.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 2<\/strong><\/p>\n\n\n\n<ul><li>Vadakan, Vibul V. \u201cA Physician Looks At The Death of Washington.\u201d Early America Review, 2005, available at: <a href=\"http:\/\/www.varsitytutors.com\/earlyamerica\/early-america-review\/volume-9\/washingtons-death\">www.varsitytutors.com\/earlyamerica\/early-america-review\/volume-9\/washingtons-death<\/a>.<\/li><li>World Health Organization, World Health Organization, www.who.int\/.<\/li><\/ul>\n\n\n\n<ul><li>Narasimhan, Ashok, and Menas C. Kafatos. \u201cWave Particle Duality, the Observer and Retrocausality.\u201d, Melissa Patterson, AIP, May 2017, doi:10.1063\/1.4982780.<\/li><li>Eccleston, Alex, et al. \u201cEpigenetics.\u201d Nature, vol. 447, no. 7143, 2007, pp. 395\u2013395., doi:10.1038\/447395a.<\/li><li>Harvard Health Publishing. \u201cWhy People Become Overweight.\u201d Harvard Health, June 2009, available at: <a href=\"http:\/\/www.health.harvard.edu\/newsweek\/Why-people-become-overweight.htm\">www.health.harvard.edu\/newsweek\/Why-people-become-overweight.htm<\/a>.<\/li><li>Rappaport, S. M., and M. T. Smith. \u201cEnvironment and Disease Risks.\u201d Science, vol. 330, no. 6003, 2010, pp. 460\u2013461., doi:10.1126\/science.1192603.<\/li><li>Willett, W. C. \u201cBalancing Life-Style and Genomics Research for Disease Prevention.\u201d Science, vol. 296, no. 5568, 2002, pp. 695\u2013698., doi:10.1126\/science.1071055.<\/li><li>Lipton, Bruce H. The Biology of Belief. Spirit 2000, Inc., 2005.<\/li><li>Lipton, Bruce H., and Steve Bhaerman. Spontaneous Evolution: Our Positive Future (and a Way to Get There from Here). Hay House, 2012.<\/li><li>Friedland, Gerald. \u201cDiscovery of the function of the heart and circulation of blood.\u201d Cardiovascular journal of Africa vol. 20,3 (2009): 160.<\/li><li>McRobbie, Donald W., et al. MRI from Picture to Proton. Cambridge University Press, 2017, 3<sup>rd<\/sup> edition.<\/li><li>Kelly, C. \u201cFunctional Correction of Short-Chain Acyl-CoA Dehydrogenase Deficiency in Transgenic Mice: Implications for Gene Therapy of Human Mitochondrial Enzyme Deficiencies.\u201d Human Molecular Genetics, vol. 6, no. 9, 1997, pp. 1451\u20131455., doi:10.1093\/hmg\/6.9.1451.<\/li><li>Zacchia, Miriam, and Patricia Preisig. \u201cLow urinary citrate: an overview.\u201d&nbsp;Journal of nephrology&nbsp;vol. 23 Suppl 16 (2010): S49-56.<\/li><li>Dudley, E., et al. \u201cTargeted Metabolomics and Mass Spectrometry.\u201d Advances in Protein Chemistry and Structural Biology, 2010, pp. 45\u201383., doi:10.1016\/b978-0-12-381264-3.00002-3.<\/li><li><strong>Tsoukalas, Dimitris<\/strong> et al. \u201cMetabolic Fingerprint of Chronic Obstructive Lung Diseases: A New Diagnostic Perspective.\u201d&nbsp;Metabolites&nbsp;vol. 9,12 290. 26 Nov. 2019, doi:10.3390\/metabo9120290<\/li><li>Raines, Jeremy K. \u201cElectromagnetic Field Interactions with the Human Body: Observed Effects and Theories.\u201d NASA, NASA, 9 Apr. 1981, ntrs.nasa.gov\/search.jsp?R=19810017132.<\/li><li>Bi\u00e9mont, C. \u201cFrom genotype to phenotype. What do epigenetics and epigenomics tell us?.\u201d&nbsp;Heredity&nbsp;vol. 105,1 (2010): 1-3. doi:10.1038\/hdy.2010.66<\/li><\/ul>\n\n\n\n<p><strong>Chapter 3<\/strong><\/p>\n\n\n\n<ul><li>\u201cPOP101: A Primer on the Future of Planet Earth.\u201d Overpopulation Is a Myth, 29 Aug. 2017, www.overpopulationisamyth.com\/.<\/li><li>Vaupel, James W. \u201cBiodemography of Human Ageing.\u201d Nature News, Nature Publishing Group, 24 Mar. 2010, www.nature.com\/articles\/nature08984#citeas.<\/li><li>\u201cMeasles Log .\u201d Http:\/\/Childhealthsafety.com\/, 2009, childhealthsafety.com\/.<\/li><li>Aunan, J R et al. \u201cMolecular and biological hallmarks of ageing.\u201d&nbsp;The British journal of surgery&nbsp;vol. 103,2 (2016): e29-46. doi:10.1002\/bjs.10053<\/li><li>Rosling, Hans. \u201cThe Joy of Stats, Hans Rosling\u2019s 200 Countries, 200 Years, 4 Minutes.\u201d BBC Four, BBC, 30 Nov. 2010, www.bbc.co.uk\/programmes\/p00cgkfk.<\/li><li>Bunker, John P. \u201cThe Role of Medical Care in Contributing to Health Improvements within Societies.\u201d International Journal of Epidemiology, vol. 30, no. 6, 2001, pp. 1260\u20131263., doi:10.1093\/ije\/30.6.1260.<\/li><li>Colditz, Graham A. \u201cEfficacy of BCG Vaccine in the Prevention of Tuberculosis.\u201d Jama, vol. 271, no. 9, 1994, p. 698., doi:10.1001\/jama.1994.03510330076038.<\/li><li>Partridge, Linda, et al. \u201cThe New Science of Ageing.\u201d Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 366, no. 1561, 2011, pp. 6\u20138., doi:10.1098\/rstb.2010.0298.<\/li><li>Grady, Deborah. \u201cLess Is More.\u201d Archives of Internal Medicine, vol. 170, no. 9, 2010, p. 749., doi:10.1001\/archinternmed.2010.90.<\/li><li>Magalh\u00e3es, Jo\u00e3o Pedro De, et al. \u201cAn Analysis of the Relationship Between Metabolism, Developmental Schedules, and Longevity Using Phylogenetic Independent Contrasts.\u201d The Journals of Gerontology: Series A, vol. 62, no. 2, 2007, pp. 149\u2013160., doi:10.1093\/gerona\/62.2.149.<\/li><li>Amir, Saira, et al. \u201cSperm Telomere Length: Diagnostic and Prognostic Biomarker in Male Infertility (Review).\u201d World Academy of Sciences Journal, 2020, doi:10.3892\/wasj.2020.31.<\/li><li><strong>Tsoukalas, Dimitris<\/strong>, et al. \u201cDiscovery of Potent Telomerase Activators: Unfolding New Therapeutic and Anti-Aging Perspectives.\u201d Molecular Medicine Reports, 2019, doi:10.3892\/mmr.2019.10614.<\/li><li><strong>Tsoukalas, Dimitris<\/strong>, et al. \u201cAssociation of Nutraceutical Supplements with Longer Telomere Length.\u201d International Journal of Molecular Medicine, 2019, doi:10.3892\/ijmm.2019.4191.<\/li><li>Vasilopoulos, Eleni et al. \u201cThe association of female and male infertility with telomere length (Review).\u201d&nbsp;International journal of molecular medicine&nbsp;vol. 44,2 (2019): 375-389. doi:10.3892\/ijmm.2019.4225<\/li><li>Tsatsakis, Aristidis, et al. \u201cDeveloping BIOTEL: A Semi-Automated Spreadsheet for Estimating Telomere Length and Biological Age.\u201d Frontiers in Genetics, vol. 10, 2019, doi:10.3389\/fgene.2019.00084.<\/li><li>Vakonaki, E.k., et al. \u201cDecreased Telomeres Length in Patients with Glioblastoma Multiform.\u201d Toxicology Letters, vol. 295, 2018, doi:10.1016\/j.toxlet.2018.06.582.<\/li><li>Ozcagli, Eren, et al. \u201cStanozolol Administration Combined with Exercise Leads to Decreased Telomerase Activity Possibly Associated with Liver Aging.\u201d International Journal of Molecular Medicine, 2018, doi:10.3892\/ijmm.2018.3644.<\/li><li>Fragkiadaki, Persefoni et al. \u201cTelomerase activity in pregnancy complications (Review).\u201d&nbsp;Molecular medicine reports&nbsp;vol. 14,1 (2016): 16-21. doi:10.3892\/mmr.2016.5231<\/li><\/ul>\n\n\n\n<p><strong>Chapter 4<\/strong><\/p>\n\n\n\n<ul><li>Ness, A. \u201cDiet, Nutrition and the Prevention of Chronic Diseases. WHO Technical Report Series 916. Report of a Joint WHO\/FSA Expert Consultation.\u201d International Journal of Epidemiology, vol. 33, no. 4, 2004, pp. 914\u2013915., doi:10.1093\/ije\/dyh209.<\/li><li>Tulchinsky, Theodore H. \u201cMicronutrient Deficiency Conditions: Global Health Issues.\u201d Public Health Reviews, vol. 32, no. 1, 2010, pp. 243\u2013255., doi:10.1007\/bf03391600.<\/li><li>Ames, B. N. \u201cLow Micronutrient Intake May Accelerate the Degenerative Diseases of Aging through Allocation of Scarce Micronutrients by Triage.\u201d Proceedings of the National Academy of Sciences, vol. 103, no. 47, 2006, pp. 17589\u201317594., doi:10.1073\/pnas.0608757103.<\/li><li>Balch, Phyllis A. Prescription for Dietary Wellness. Penguin Group, 2003.<\/li><li>From Rio to Rio+20: Progress and Challenges since&nbsp;the 1992 Earth Summit United Nations Conference on&nbsp;Sustainable Development&nbsp;United Nations Department of&nbsp;Public Information, June 2012<\/li><li>Musio, Silvia, et al. \u201cA Key Regulatory Role for Histamine in Experimental Autoimmune Encephalomyelitis: Disease Exacerbation in Histidine Decarboxylase-Deficient Mice.\u201d The Journal of Immunology, vol. 176, no. 1, 2005, pp. 17\u201326., doi:10.4049\/jimmunol.176.1.17.<\/li><li>Anderson, Sandra D. \u201cHow Does Exercise Cause Asthma Attacks?\u201d Current Opinion in Allergy and Clinical Immunology, vol. 6, no. 1, 2006, pp. 37\u201342., doi:10.1097\/01.all.0000199797.02423.78.<\/li><li>Schomburg, Lutz. \u201cSelenium, Selenoproteins and the Thyroid Gland: Interactions in Health and Disease.\u201d Nature Reviews Endocrinology, vol. 8, no. 3, 2011, pp. 160\u2013171., doi:10.1038\/nrendo.2011.174.<\/li><li>Grenham, Sue, et al. \u201cBrain Gut Microbe Communication in Health and Disease.\u201d Frontiers in Physiology, vol. 2, 2011, doi:10.3389\/fphys.2011.00094.<\/li><li>\u201cAutoimmune Info \u2013 American Autoimmune Related Diseases Association.\u201d AARDA, 2018, www.aarda.org\/.<\/li><li>Freedman, D. M., et al. \u201cVitamin D and Cancer Mortality.\u201d Cancer Epidemiology Biomarkers &amp; Prevention, vol. 18, no. 1, 2009, pp. 359\u2013359., doi:10.1158\/1055-9965.epi-08-0633.<\/li><li>Atoum, Manar, and Foad Alzoughool. \u201cVitamin D and Breast Cancer: Latest Evidence and Future Steps.\u201d Breast Cancer: Basic and Clinical Research, vol. 11, 2017, p. 117822341774981., doi:10.1177\/1178223417749816.<\/li><li>Gorham, Edward D., et al. \u201cVitamin D and Prevention of Colorectal Cancer.\u201d The Journal of Steroid Biochemistry and Molecular Biology, vol. 97, no. 1-2, 2005, pp. 179\u2013194., doi:10.1016\/j.jsbmb.2005.06.018.<\/li><li>Volkov, I, et al. \u201cSuccessful Treatment of Recurrent Aphthous Stomatitis of Any Origin with Vitamin B12 (Irrespective of Its Blood Level).\u201d The Internet Journal of Family Practice, vol. 5, no. 1, 2007, doi:10.5580\/2477.<\/li><li>\u201cVitamin B12 Link to Alzheimer\u2019s Backed by Study.\u201d BBC News, BBC, 19 Oct. 2010, www.bbc.com\/news\/health-11569602.<\/li><li>Enns, Cecilia &amp; Goldman, J.D. &amp; Cook, A.. (1997). Trends in food and nutrient intakes by adults: NFCS 1977-78, CSFII 1989-91, and CSFII 1994-95. Fam Econ Nutr Rev. 10.<\/li><li>Bernatsky, Sasha et al. \u201cAssociations between ambient fine particulate levels and disease activity in patients with systemic lupus erythematosus (SLE).\u201d&nbsp;Environmental health perspectives&nbsp;vol. 119,1 (2011): 45-9. doi:10.1289\/ehp.1002123<\/li><li>Elias, Kevin M., et al. \u201cRetinoic Acid Inhibits Th17 Polarization and Enhances FoxP3 Expression through a Stat-3\/Stat-5 Independent Signaling Pathway.\u201d Blood, vol. 111, no. 3, 2008, pp. 1013\u20131020., doi:10.1182\/blood-2007-06-096438.<\/li><li>Ebers, G. C., et al. \u201cVitamin D Intake and Incidence of Multiple Sclerosis.\u201d Neurology, vol. 63, no. 5, 2004, pp. 939\u2013939., doi:10.1212\/wnl.63.5.939.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 5<\/strong><\/p>\n\n\n\n<ul><li>Tanaka, K et al. \u201cIsovaleric acidemia: a new genetic defect of leucine metabolism.\u201d&nbsp;Proceedings of the National Academy of Sciences of the United States of America&nbsp;vol. 56,1 (1966): 236-42. doi:10.1073\/pnas.56.1.236<\/li><li>Radzicka, A, and R Wolfenden. \u201cA Proficient Enzyme.\u201d Science, vol. 267, no. 5194, 1995, pp. 90\u201393., doi:10.1126\/science.7809611.<\/li><li><strong>Tsoukalas, Dimitris<\/strong>, et al. \u201cTargeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases.\u201d Frontiers in Molecular Biosciences, vol. 6, 2019, doi:10.3389\/fmolb.2019.00120.<\/li><li>Vockley, Jerry, and Regina Ensenauer. \u201cIsovaleric Acidemia: New Aspects of Genetic and Phenotypic Heterogeneity.\u201d American Journal of Medical Genetics Part C: Seminars in Medical Genetics, vol. 142C, no. 2, 2006, pp. 95\u2013103., doi:10.1002\/ajmg.c.30089.<\/li><li>Horning, E C, and M G Horning. \u201cMetabolic Profiles: Gas-Phase Methods for Analysis of Metabolites.\u201d Clinical Chemistry, vol. 17, no. 8, 1971, pp. 802\u2013809., doi:10.1093\/clinchem\/17.8.802.<\/li><li><strong>Tsoukalas, Dimitris <\/strong>et al. Metabolic Fingerprint of Chronic Obstructive Lung Diseases: A New Diagnostic Perspective. Metabolites 2019, 9(12), 290;&nbsp; 26 November 2019 doi:&nbsp;<a href=\"https:\/\/dx.doi.org\/10.3390%2Fmetabo9120290\">10.3390\/metabo9120290<\/a><\/li><li>\u201cThe Fingerprints of Diabetes\u2026and Other Diseases.\u201d Harvard Magazine, 3 Mar. 2014, available at: harvardmagazine.com\/2011\/05\/the-fingerprints-of-diabetes-and-other-diseases.<\/li><li>Pauling, L., et al. \u201cQuantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography.\u201d Proceedings of the National Academy of Sciences, vol. 68, no. 10, 1971, pp. 2374\u20132376., doi:10.1073\/pnas.68.10.2374.<\/li><li>Jansson, Janet, et al. \u201cMetabolomics Reveals Metabolic Biomarkers of Crohn\u2019s Disease.\u201d PLoS ONE, vol. 4, no. 7, 2009, doi:10.1371\/journal.pone.0006386.<\/li><li>Seeger, Karsten. \u201cMetabolic Changes in Autoimmune Diseases.\u201d Current Drug Discovery Technologies, vol. 6, no. 4, 2009, pp. 256\u2013261., doi:10.2174\/157016309789869074.<\/li><li>Spratlin, J. L., et al. \u201cClinical Applications of Metabolomics in Oncology: A Review.\u201d Clinical Cancer Research, vol. 15, no. 2, 2009, pp. 431\u2013440., doi:10.1158\/1078-0432.ccr-08-1059.<\/li><li>Lewis, Gregory D., and Robert E. Gerszten. \u201cApplication of Metabolomics to Cardiovascular Biomarker and Pathway Discovery.\u201d Clinical Proteomics, 2008, pp. 279\u2013293., doi:10.1002\/9783527622153.ch19.\\<\/li><li>Kim, Ji Young, et al. \u201cMetabolic Profiling of Plasma in Overweight\/Obese and Lean Men Using Ultra Performance Liquid Chromatography and Q-TOF Mass Spectrometry (UPLC\u2212Q-TOF MS).\u201d Journal of Proteome Research, vol. 9, no. 9, 2010, pp. 4368\u20134375., doi:10.1021\/pr100101p.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 6<\/strong><\/p>\n\n\n\n<ul><li>Tanaka, K., et al. \u201cIsovaleric Acidemia: a New Genetic Defect of Leucine Metabolism.\u201d Proceedings of the National Academy of Sciences, vol. 56, no. 1, 1966, pp. 236\u2013242., doi:10.1073\/pnas.56.1.236.<\/li><li>Radzicka, A, and R Wolfenden. \u201cA Proficient Enzyme.\u201d Science, vol. 267, no. 5194, 1995, pp. 90\u201393., doi:10.1126\/science.7809611.<\/li><li>Vockley, Jerry, and Regina Ensenauer. \u201cIsovaleric Acidemia: New Aspects of Genetic and Phenotypic Heterogeneity.\u201d American Journal of Medical Genetics Part C: Seminars in Medical Genetics, vol. 142C, no. 2, 2006, pp. 95\u2013103., doi:10.1002\/ajmg.c.30089.<\/li><li>Horning, E C, and M G Horning. \u201cMetabolic Profiles: Gas-Phase Methods for Analysis of Metabolites.\u201d Clinical Chemistry, vol. 17, no. 8, 1971, pp. 802\u2013809., doi:10.1093\/clinchem\/17.8.802.<\/li><li>\u201cThe Fingerprints of Diabetes\u2026and Other Diseases.\u201d Harvard Magazine, 3 Mar. 2014, available at: harvardmagazine.com\/2011\/05\/the-fingerprints-of-diabetes-and-other-diseases.<\/li><li>Ford, Earl S, et al. \u201cHealthy Living Is the Best Revenge:Findings From the European Prospective Investigation Into Cancer and Nutrition-Potsdam Study.\u201d Archives of Internal Medicine, vol. 169, no. 15, 2009, p. 1355., doi:10.1001\/archinternmed.2009.237.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 7<\/strong><\/p>\n\n\n\n<ul><li>Pauling, L., et al. \u201cQuantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography.\u201d Proceedings of the National Academy of Sciences, vol. 68, no. 10, 1971, pp. 2374\u20132376., doi:10.1073\/pnas.68.10.2374.<\/li><li>Jansson, Janet, et al. \u201cMetabolomics Reveals Metabolic Biomarkers of Crohn\u2019s Disease.\u201d PLoS ONE, vol. 4, no. 7, 2009, doi:10.1371\/journal.pone.0006386.<\/li><li>Seeger, Karsten. \u201cMetabolic Changes in Autoimmune Diseases.\u201d Current Drug Discovery Technologies, vol. 6, no. 4, 2009, pp. 256\u2013261., doi:10.2174\/157016309789869074.<\/li><li>Spratlin, J. L., et al. \u201cClinical Applications of Metabolomics in Oncology: A Review.\u201d Clinical Cancer Research, vol. 15, no. 2, 2009, pp. 431\u2013440., doi:10.1158\/1078-0432.ccr-08-1059.<\/li><li>Lewis, Gregory D., and Robert E. Gerszten. \u201cApplication of Metabolomics to Cardiovascular Biomarker and Pathway Discovery.\u201d Clinical Proteomics, 2008, pp. 279\u2013293., doi:10.1002\/9783527622153.ch19.\\<\/li><li>Kim, Ji Young, et al. \u201cMetabolic Profiling of Plasma in Overweight\/Obese and Lean Men Using Ultra Performance Liquid Chromatography and Q-TOF Mass Spectrometry (UPLC\u2212Q-TOF MS).\u201d Journal of Proteome Research, vol. 9, no. 9, 2010, pp. 4368\u20134375., doi:10.1021\/pr100101p.<\/li><li>Chakravarti, Aravinda. \u201cGenomics Is Not Enough.\u201d Science Mag, 7 Oct. 2011,available at: science.sciencemag.org\/content\/334\/6052\/15.<\/li><li>Lord, Richard S., and J. Alexander. Bralley. Laboratory Evaluations for Integrative and Functional Medicine. 2nd ed., Genova Diagnostics, 2008.<\/li><li>German, J. B., et al. \u201cMetabolomics and Individual Metabolic Assessment: The Next Great Challenge for Nutrition.\u201d The Journal of Nutrition, vol. 132, no. 9, 2002, pp. 2486\u20132487., doi:10.1093\/jn\/132.9.2486.<\/li><li>German, J. Bruce, et al. \u201cMetabolomics in Practice: Emerging Knowledge to Guide Future Dietetic Advice toward Individualized Health.\u201d Journal of the American Dietetic Association, vol. 105, no. 9, 2005, pp. 1425\u20131432., doi:10.1016\/j.jada.2005.06.006.<\/li><li>Zivkovic, Angela M, and J Bruce German. \u201cMetabolomics for Assessment of Nutritional Status.\u201d Current Opinion in Clinical Nutrition and Metabolic Care, vol. 12, no. 5, 2009, pp. 501\u2013507., doi:10.1097\/mco.0b013e32832f1916.<\/li><li>Pieczenik, Steve R., and John Neustadt. \u201cMitochondrial Dysfunction and Molecular Pathways of Disease.\u201d Experimental and Molecular Pathology, vol. 83, no. 1, 2007, pp. 84\u201392., doi:10.1016\/j.yexmp.2006.09.008.<\/li><li>Indrio, Flavia, et al. \u201cRegurgitation in Healthy and Non Healthy Infants.\u201d Italian Journal of Pediatrics, 9 Dec. 2009, doi:https:\/\/doi.org\/10.1186\/1824-7288-35-39.<\/li><li>Seely, Ellen W. \u201cEditorial Overview.\u201d Current Opinion in Endocrinology, Diabetes and Obesity, vol. 17, no. 3, 2010, p. 187., doi:10.1097\/med.0b013e3283394ef4.<\/li><li>Bournat, Juan C, and Chester W Brown. \u201cMitochondrial Dysfunction in Obesity.\u201d Current Opinion in Endocrinology, Diabetes and Obesity, vol. 17, no. 5, 2010, pp. 446\u2013452., doi:10.1097\/med.0b013e32833c3026.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 8<\/strong><\/p>\n\n\n\n<ul><li><strong>Tsoukalas, Dimitris<\/strong>, et al. \u201cAnthropogenic Pressure and Lifestyle Are the Underlying Cause of Pandemic Chronic Diseases.\u201d Journal of Siberian Federal University. Biology, 2019, pp. 233\u2013243., doi:10.17516\/1997-1389-0297.<\/li><li><a href=\"http:\/\/www.usatoday.com\/educate\/college\/firstyear\/articles\/20050327.htm\" target=\"_blank\" rel=\"noreferrer noopener\">www.usatoday.com\/educate\/college\/firstyear\/articles\/20050327.htm<\/a><\/li><li>Cohen, Sheldon, et al. \u201cChronic Stress, Glucocorticoid Receptor Resistance, Inflammation, and Disease Risk.\u201d PNAS, 17 Apr. 2012, www.pnas.org\/. <a href=\"https:\/\/doi.org\/10.1073\/pnas.1118355109\">https:\/\/doi.org\/10.1073\/pnas.1118355109<\/a><\/li><li>Boone, Jeffrey L, and Jeffrey P Anthony. \u201cEvaluating the impact of stress on systemic disease: the MOST protocol in primary care.\u201d&nbsp;The Journal of the American Osteopathic Association&nbsp;vol. 103,5 (2003): 239-46.<\/li><li>Selye, H. \u201cStress and Disease.\u201d Science, vol. 122, no. 3171, 1955, pp. 625\u2013631., doi:10.1126\/science.122.3171.625.<\/li><li>Slavich, George M. \u201cLife Stress and Health.\u201d Teaching of Psychology, vol. 43, no. 4, 2016, pp. 346\u2013355., doi:10.1177\/0098628316662768.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 9<\/strong><\/p>\n\n\n\n<ul><li>Simopoulos, Artemis P. \u201cThe Importance of the Omega-6\/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases.\u201d Experimental Biology and Medicine, vol. 233, no. 6, 2008, pp. 674\u2013688., doi:10.3181\/0711-mr-311.<\/li><li>Mesnage, Robin, et al. \u201cGut Microbiome Metagenomics to Understand How Xenobiotics Impact Human Health.\u201d Current Opinion in Toxicology, vol. 11-12, 2018, pp. 51\u201358., doi:10.1016\/j.cotox.2019.02.002.<\/li><li>Papamichael, Maria Michelle, et al. \u201cWeight Status and Respiratory Health in Asthmatic Children.\u201d Lung, vol. 197, no. 6, 2019, pp. 777\u2013782., doi:10.1007\/s00408-019-00273-w.<\/li><li>Papamichael, M. M., et al. \u201cEfficacy of a Mediterranean Diet Supplemented with Fatty Fish in Ameliorating Inflammation in Paediatric Asthma: a Randomised Controlled Trial.\u201d Journal of Human Nutrition and Dietetics, vol. 32, no. 2, 2018, pp. 185\u2013197., doi:10.1111\/jhn.12609.<\/li><li><strong>Tsoukalas, Dimitris<\/strong>, et al. \u201cApplication of Metabolomics Part II: Focus on Fatty Acids and Their Metabolites in Healthy Adults.\u201d International Journal of Molecular Medicine, 2018, doi:10.3892\/ijmm.2018.3989.<\/li><li>Hubbard, L. Ron. Clear Body, Clear Mind: the Effective Purification Program. Bridge Publications, 1990, 1<sup>st<\/sup> edition.<\/li><li>Costa, Chiara, et al. \u201cCurrent Evidence on the Effect of Dietary Polyphenols Intake on Chronic Diseases.\u201d Food and Chemical Toxicology, vol. 110, 2017, pp. 286\u2013299., doi:10.1016\/j.fct.2017.10.023.<\/li><li>Engin, Ayse Basak, et al. \u201cDo Flavanols-Rich Natural Products Relieve Obesity-Related Insulin Resistance?\u201d Food and Chemical Toxicology, vol. 112, 2018, pp. 157\u2013167, doi:10.1016\/j.fct.2017.12.055.<\/li><li>Nitulescu, George, et al. \u201cThe Akt Pathway in Oncology Therapy and beyond (Review).\u201d International Journal of Oncology, 2018, doi:10.3892\/ijo.2018.4597.<\/li><li>Zanfirescu, Anca, et al. \u201cA Review of the Alleged Health Hazards of Monosodium Glutamate.\u201d Comprehensive Reviews in Food Science and Food Safety, vol. 18, no. 4, 2019, pp. 1111\u20131134., doi:10.1111\/1541-4337.12448.<\/li><li>\u201cHealthy Eating Plate.\u201d The Nutrition Source, 22 Nov. 2019, available at: www.hsph.harvard.edu\/nutritionsource\/what-should-you-eat\/pyramid\/.<\/li><li>Cox, B. D, and M. J Whichelow. \u201cFrequent Consumption of Red Meat Is Not Risk Factor for Cancer.\u201d Bmj, vol. 315, no. 7114, 1997, pp. 1018\u20131018., doi:10.1136\/bmj.315.7114.1018a.<\/li><li>Carroll, K K. \u201cDietary Fats and Cancer.\u201d The American Journal of Clinical Nutrition, vol. 53, no. 4, 1991, doi:10.1093\/ajcn\/53.4.1064s.<\/li><li>Mie, Axel, et al. \u201cHuman Health Implications of Organic Food and Organic Agriculture: a Comprehensive Review.\u201d Environmental Health, vol. 16, no. 1, 2017, doi:10.1186\/s12940-017-0315-4.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 10<\/strong><\/p>\n\n\n\n<p>Pludowski, Pawel, et al. \u201cVitamin D Effects on Musculoskeletal Health, Immunity, Autoimmunity, Cardiovascular Disease, Cancer, Fertility, Pregnancy, Dementia and Mortality\u2014A Review of Recent Evidence.\u201d Autoimmunity Reviews, vol. 12, no. 10, 2013, pp. 976\u2013989., doi:10.1016\/j.autrev.2013.02.004.<\/p>\n\n\n\n<ul><li>Heaney, Robert P. \u201cAssessing Vitamin D Status.\u201d Current Opinion in Clinical Nutrition and Metabolic Care, vol. 14, no. 5, 2011, pp. 440\u2013444., doi:10.1097\/mco.0b013e328348ed85.<\/li><li>Garland, Cedric F., et al. \u201cVitamin D for Cancer Prevention: Global Perspective.\u201d Annals of Epidemiology, vol. 19, no. 7, 2009, pp. 468\u2013483., doi:10.1016\/j.annepidem.2009.03.021.<\/li><li>Atoum, Manar, and Foad Alzoughool. \u201cVitamin D and Breast Cancer: Latest Evidence and Future Steps.\u201d Breast Cancer: Basic and Clinical Research, vol. 11, 2017, p. 117822341774981., doi:10.1177\/1178223417749816.<\/li><li>Gorham, Edward D., et al. \u201cVitamin D and Prevention of Colorectal Cancer.\u201d The Journal of Steroid Biochemistry and Molecular Biology, vol. 97, no. 1-2, 2005, pp. 179\u2013194., doi:10.1016\/j.jsbmb.2005.06.018.<\/li><li>\u201cUnraveling the Enigma of Vitamin D.\u201d National Academy of Sciences, Oct. 2000, available at: www.nasonline.org\/publications\/beyond-discovery\/vitamin-d.pdf.<\/li><li>Pilz, Stefan, et al. \u201cVitamin D Status and Arterial Hypertension: a Systematic Review.\u201d Nature Reviews Cardiology, vol. 6, no. 10, 2009, pp. 621\u2013630., doi:10.1038\/nrcardio.2009.135.<\/li><li>Kinney, Dennis K., et al. \u201cEnvironmental Risk Factors for Autism: Do They Help Cause De Novo Genetic Mutations That Contribute to the Disorder?\u201d Medical Hypotheses, vol. 74, no. 1, 2010, pp. 102\u2013106., doi:10.1016\/j.mehy.2009.07.052.<\/li><li>Kulie, T., et al. \u201cVitamin D: An Evidence-Based Review.\u201d The Journal of the American Board of Family Medicine, vol. 22, no. 6, 2009, pp. 698\u2013706., doi:10.3122\/jabfm.2009.06.090037.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 11<\/strong><\/p>\n\n\n\n<ul><li>Sedelmeier, Gottfried, and Joerg Sedelmeier. \u201cTop 200 Drugs by Worldwide Sales 2016.\u201d&nbsp;Chimia&nbsp;vol. 71,10 (2017): 730. doi:10.2533\/chimia.2017.730<\/li><li>Quigley, Eamonn M.m., and Rodrigo Quera. \u201cSmall Intestinal Bacterial Overgrowth: Roles of Antibiotics, Prebiotics, and Probiotics.\u201d Gastroenterology, vol. 130, no. 2, 2006, doi:10.1053\/j.gastro.2005.11.046.<\/li><li>Center for Drug Evaluation and Research. \u201cPossible Increased Risk of Fractures with the Use of PPIs.\u201d U.S. Food and Drug Administration, FDA, 25 May 2010, available at: <a href=\"http:\/\/www.fda.gov\/drugs\/postmarket-drug-safety-information-patients-and-providers\/fda-drug-safety-communication-possible-increased-risk-fractures-hip-wrist-and-spine-use-proton-pump\">www.fda.gov\/drugs\/postmarket-drug-safety-information-patients-and-providers\/fda-drug-safety-communication-possible-increased-risk-fractures-hip-wrist-and-spine-use-proton-pump<\/a>.<\/li><li>Ali, Tauseef, et al. \u201cLong-Term Safety Concerns with Proton Pump Inhibitors.\u201d The American Journal of Medicine, vol. 122, no. 10, 2009, pp. 896\u2013903., doi:10.1016\/j.amjmed.2009.04.014.<\/li><li>Rabin, Roni Caryn. \u201cCombating Acid Reflux May Bring Host of Ills.\u201d The New York Times, The New York Times, 25 June 2012, available at: well.blogs.nytimes.com\/2012\/06\/25\/combating-acid-reflux-may-bring-host-of-ills\/.<\/li><li>\u201cUse of Stomach Drugs Debated.\u201d NHS Choices, NHS, 11 May 2010, available at: www.nhs.uk\/news\/2010\/05may\/pages\/ppi-stomach-drugs-harm-vs-good.aspx.<\/li><li>Piessevaux, H., et al. \u201cDyspeptic Symptoms in the General Population: a Factor and Cluster Analysis of Symptom Groupings.\u201d Neurogastroenterology &amp; Motility, vol. 21, no. 4, 2009, pp. 378\u2013388., doi:10.1111\/j.1365-2982.2009.01262.x.<\/li><li>Heading, R C. \u201cPrevalence of upper gastrointestinal symptoms in the general population: a systematic review.\u201d&nbsp;Scandinavian journal of gastroenterology. Supplement&nbsp;vol. 231 (1999): 3-8.<\/li><li>Lyte, Mark. \u201cProbiotics Function Mechanistically as Delivery Vehicles for Neuroactive Compounds: Microbial Endocrinology in the Design and Use of Probiotics.\u201d BioEssays, vol. 33, no. 8, 2011, pp. 574\u2013581., doi:10.1002\/bies.201100024.<\/li><li>Reid, Gregor. \u201cNeuroactive Probiotics.\u201d BioEssays, vol. 33, no. 8, 2011, pp. 562\u2013562., doi:10.1002\/bies.201100074.<\/li><li>\u201cKurzweilaccelerating Intelligence.\u201d Kurzweil That Gut Feeling How Stomach Bacteria Impact Brain Chemistry and Behavior Comments, available at: www.kurzweilai.net\/that-gut-feeling-how-stomach-bacteria-impact-brain-chemistry-and-behavior.<\/li><li>Hong, Young-Shick, et al. \u201cMetabonomic Understanding of Probiotic Effects in Humans With Irritable Bowel Syndrome.\u201d Journal of Clinical Gastroenterology, vol. 45, no. 5, 2011, pp. 415\u2013425., doi:10.1097\/mcg.0b013e318207f76c.<\/li><li>Jim\u00e9nez, M. Bixquert. \u201cTreatment of Irritable Bowel Syndrome with Probiotics: An Etiopathogenic Approach at Last?\u201d Revista Espa\u00f1ola De Enfermedades Digestivas, vol. 101, no. 8, 2009, doi:10.4321\/s1130-01082009000800006.<\/li><li>Bischoff, Stephan C, et al. \u201cIntestinal Permeability \u2013 a New Target for Disease Prevention and Therapy.\u201d BMC Gastroenterology, vol. 14, no. 1, 2014, doi:10.1186\/s12876-014-0189-7.<\/li><li>Mu, Qinghui, et al. \u201cLeaky Gut As a Danger Signal for Autoimmune Diseases.\u201d Frontiers in Immunology, vol. 8, 2017, doi:10.3389\/fimmu.2017.00598.<\/li><li>Demeo, Mark T., et al. \u201cIntestinal Permeation and Gastrointestinal Disease.\u201d Journal of Clinical Gastroenterology, vol. 34, no. 4, 2002, pp. 385\u2013396., doi:10.1097\/00004836-200204000-00003.<\/li><li>Liu, Z et al. \u201cTight junctions, leaky intestines, and pediatric diseases.\u201d&nbsp;Acta paediatrica (Oslo, Norway : 1992)&nbsp;vol. 94,4 (2005): 386-93. doi:10.1111\/j.1651-2227.2005.tb01904.x<\/li><li>Fasano, Alessio. \u201cZonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.\u201d&nbsp;Physiological reviews&nbsp;vol. 91,1 (2011): 151-75. doi:10.1152\/physrev.00003.2008<\/li><li>Vine, D F et al. \u201cEffect of dietary fatty acids on the intestinal permeability of marker drug compounds in excised rat jejunum.\u201d&nbsp;The Journal of pharmacy and pharmacology&nbsp;vol. 54,6 (2002): 809-19. doi:10.1211\/0022357021779159<\/li><\/ul>\n\n\n\n<p><strong>Chapter 12<\/strong><\/p>\n\n\n\n<ul><li>Danner, Deborah D., et al. \u201cPositive Emotions in Early Life and Longevity: Findings from the Nun Study.\u201d Journal of Personality and Social Psychology, vol. 80, no. 5, 2001, pp. 804\u2013813., doi:10.1037\/0022-3514.80.5.804.<\/li><li>Nakazawa, Donna Jackson. The Autoimmune Epidemic. Simon &amp; Schuster, 2009.<\/li><li>Papamichael, Maria Michelle, et al. \u201cUrinary Organic Acids as Biomarkers in the Assessment of Pulmonary Function in Children with Asthma.\u201d Nutrition Research, vol. 61, 2019, pp. 31\u201340., doi:10.1016\/j.nutres.2018.10.004.<\/li><li>\u201cCell Damage and Autoimmunity Colloquium Draws Internationally Known Researchers.\u201d AARDA, available at: www.aarda.org\/.<\/li><li>Yang, Chen-Yen, et al. \u201cThe Implication of Vitamin D and Autoimmunity: a Comprehensive Review.\u201d Clinical Reviews in Allergy &amp; Immunology, vol. 45, no. 2, 2013, pp. 217\u2013226., doi:10.1007\/s12016-013-8361-3.<\/li><li>Elias, Kevin M et al. \u201cRetinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3\/Stat-5 independent signaling pathway.\u201d&nbsp;Blood&nbsp;vol. 111,3 (2008): 1013-20. doi:10.1182\/blood-2007-06-096438<\/li><li>Shaikh, Saame Raza, and Michael Edidin. \u201cPolyunsaturated Fatty Acids, Membrane Organization, T Cells, and Antigen Presentation.\u201d The American Journal of Clinical Nutrition, vol. 84, no. 6, 2006, pp. 1277\u20131289., doi:10.1093\/ajcn\/84.6.1277.<\/li><li>\u201cHuman Molecular Genetics: Oxford Academic.\u201d OUP Academic, Oxford University Press, 1 Jan. 1753, academic.oup.com\/hmg.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 13<\/strong><\/p>\n\n\n\n<ul><li>\u201cLegislative Activities and History.\u201d National Cancer Institute, <a href=\"http:\/\/www.cancer.gov\/about-nci\/legislative\">www.cancer.gov\/about-nci\/legislative<\/a>. (??)<\/li><li>Jemal, Ahmedin, et al. \u201cGlobal Cancer Statistics.\u201d CA: A Cancer Journal for Clinicians, vol. 61, no. 2, 2011, pp. 69\u201390., doi:10.3322\/caac.20107.<\/li><li>\u201cIOPscience.\u201d IOPscience, iopscience.iop.org\/.<\/li><li>Dunham, Will. \u201cCancer to Pass Heart Disease as No. 1 Killer.\u201d Reuters, Thomson Reuters, 9 Dec. 2008, available at: www.reuters.com\/article\/us-cancer-world\/cancer-to-pass-heart-disease-as-no-1-killer-idUSN0918012220081209.<\/li><li>Zimmerman, Michael R. \u201cAn Experimental Study of Mummification Pertinent to the Antiquity of Cancer.\u201d Cancer, vol. 40, no. 3, 1977, pp. 1358\u20131362., doi:10.1002\/1097-0142(197709)40:33.0.co;2-j.<\/li><li>\u201cPhysical Activity and Cancer Fact Sheet.\u201d National Cancer Institute, 10 Feb. 2020, available at: www.cancer.gov\/about-cancer\/causes-prevention\/risk\/obesity\/physical-activity-fact-sheet.<\/li><li>Hsu, Isabel R et al. \u201cMetabolic syndrome, hyperinsulinemia, and cancer.\u201d&nbsp;The American journal of clinical nutrition&nbsp;vol. 86,3 (2007): s867-71. doi:10.1093\/ajcn\/86.3.867S<\/li><li>Macrae, Fiona. \u201cCancer \u2018Is Purely Man-Made\u2019 Say Scientists after Finding Almost No Trace of Disease in Egyptian Mummies.\u201d Daily Mail Online, Associated Newspapers, 15 Oct. 2010, available at: www.dailymail.co.uk\/sciencetech\/article-1320507\/Cancer-purely-man-say-scientists-finding-trace-disease-Egyptian-mummies.html.<\/li><li>David, A. Rosalie, and Michael R. Zimmerman. \u201cCancer: an Old Disease, a New Disease or Something in between?\u201d Nature Reviews Cancer, vol. 10, no. 10, 2010, pp. 728\u2013733., doi:10.1038\/nrc2914.<\/li><li>Gorham, Edward D et al. \u201cOptimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis.\u201d&nbsp;American journal of preventive medicine&nbsp;vol. 32,3 (2007): 210-6. doi:10.1016\/j.amepre.2006.11.004<\/li><li>Garland, Cedric F et al. \u201cVitamin D and prevention of breast cancer: pooled analysis.\u201d&nbsp;The Journal of steroid biochemistry and molecular biology&nbsp;vol. 103,3-5 (2007): 708-11. doi:10.1016\/j.jsbmb.2006.12.007<\/li><li>Devaraj, S et al. \u201cLow vitamin D levels in Northern American adults with the metabolic syndrome.\u201d&nbsp;Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme&nbsp;vol. 43,1 (2011): 72-4. doi:10.1055\/s-0030-1268485<\/li><li>Laino, Charlene. \u201cMultivitamins May Cut Breast Cancer Risk.\u201d WebMD, WebMD, 19 Apr. 2010, available at: www.webmd.com\/breast-cancer\/news\/20100419\/multivitamins-may-cut-breast-cancer-risk.<\/li><li>The American Cancer Society and Editorial Content Team. \u201cFamily Cancer Syndromes.\u201d American Cancer Society, 2018, available at: www.cancer.org\/cancer\/cancer-causes\/genetics\/family-cancer-syndromes.html.<\/li><li>Esteller, Manel. \u201cEpigenetics in Cancer.\u201d New England Journal of Medicine, vol. 358, no. 11, 2008, pp. 1148\u20131159., doi:10.1056\/nejmra072067.<\/li><li>Roukos, Dimitrios H. \u201cGenome-wide association studies: how predictable is a person\u2019s cancer risk?.\u201d&nbsp;Expert review of anticancer therapy&nbsp;vol. 9,4 (2009): 389-92. doi:10.1586\/era.09.12<\/li><li>Greenhalgh, Trisha, et al. \u201cLess Research Is Needed.\u201d Speaking of Medicine, 18 May 2020, available at: blogs.plos.org\/speakingofmedicine\/2012\/06\/25\/less-research-is-needed\/.<\/li><li>Barrett, Mike, et al. \u201cCompiled Proof That Natural Healing Is Embedded in Natural Foods.\u201d Natural Society, 17 June 2015, available at: naturalsociety.com\/compiled-proof-natural-healing-foods-key-optimal-health\/.<\/li><li>\u201cHerbal Medicine Research and Global Health: an Ethical Analysis.\u201d World Health Organization, World Health Organization, 4 Mar. 2011, available at: <a href=\"http:\/\/www.who.int\/bulletin\/volumes\/86\/8\/07-042820\/en\/\">www.who.int\/bulletin\/volumes\/86\/8\/07-042820\/en\/<\/a>.<\/li><li>\u201cKurzweilaccelerating Intelligence.\u201d Kurzweil Researchers Identify Biochemical Functions for Most of the Human Genome Comments, 7 Sept. 2012, available at: <a href=\"http:\/\/www.kurzweilai.net\/researchers-identify-biochemical-functions-for-most-of-the-human-genome\">www.kurzweilai.net\/researchers-identify-biochemical-functions-for-most-of-the-human-genome<\/a>.<\/li><li>Padayatty, S J, and M Levine. \u201cVitamin C: the known and the unknown and Goldilocks.\u201d&nbsp;Oral diseases&nbsp;vol. 22,6 (2016): 463-93. doi:10.1111\/odi.12446<\/li><li>Levine, Mark et al. \u201cVitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.\u201d&nbsp;Advances in nutrition (Bethesda, Md.)&nbsp;vol. 2,2 (2011): 78-88. doi:10.3945\/an.110.000109<\/li><li>Chen, Qi et al. \u201cPharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.\u201d&nbsp;Proceedings of the National Academy of Sciences of the United States of America&nbsp;vol. 105,32 (2008): 11105-9. doi:10.1073\/pnas.0804226105<\/li><li>Padayatty, Sebastian J et al. \u201cIntravenously administered vitamin C as cancer therapy: three cases.\u201d&nbsp;CMAJ : Canadian Medical Association journal = journal de l\u2019Association medicale canadienne&nbsp;vol. 174,7 (2006): 937-42. doi:10.1503\/cmaj.050346<\/li><li>Roomi, M Waheed, et al. \u201cModulation of N-Methyl-N-Nitrosourea Induced Mammary Tumors in Sprague\u2013Dawley Rats by Combination of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract.\u201d Breast Cancer Research, vol. 7, no. 3, 2005, doi:10.1186\/bcr989.<\/li><li>Dringen, Ralf. \u201cMetabolism and Functions of Glutathione in Brain.\u201d Progress in Neurobiology, vol. 62, no. 6, 2000, pp. 649\u2013671., doi:10.1016\/s0301-0082(99)00060-x.<\/li><li>Block, Keith I et al. \u201cImpact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials.\u201d&nbsp;International journal of cancer&nbsp;vol. 123,6 (2008): 1227-39. doi:10.1002\/ijc.23754<\/li><li>Block, Keith I., et al. \u201cImpact of Antioxidant Supplementation on Chemotherapeutic Efficacy: A Systematic Review of the Evidence from Randomized Controlled Trials.\u201d Cancer Treatment Reviews, vol. 33, no. 5, 2007, pp. 407\u2013418., doi:10.1016\/j.ctrv.2007.01.005.<\/li><li>Riordan, Hugh D et al. \u201cIntravenous ascorbic acid: protocol for its application and use.\u201d&nbsp;Puerto Rico health sciences journal&nbsp;vol. 22,3 (2003): 287-90.<\/li><li>Bowie, A G, and L A O\u2019Neill. \u201cVitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase.\u201d&nbsp;Journal of immunology (Baltimore, Md. : 1950)&nbsp;vol. 165,12 (2000): 7180-8. doi:10.4049\/jimmunol.165.12.7180<\/li><li>Ahsan, H et al. \u201cPro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin.\u201d&nbsp;Chemico-biological interactions&nbsp;vol. 121,2 (1999): 161-75. doi:10.1016\/s0009-2797(99)00096-4<\/li><li>Arbiser, J L et al. \u201cCurcumin is an in vivo inhibitor of angiogenesis.\u201d&nbsp;Molecular medicine (Cambridge, Mass.)&nbsp;vol. 4,6 (1998): 376-83.<\/li><li>Jee, S H et al. \u201cCurcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells.\u201d&nbsp;The Journal of investigative dermatology&nbsp;vol. 111,4 (1998): 656-61. doi:10.1046\/j.1523-1747.1998.00352.x<\/li><li>Lin, J K, and S Y Lin-Shiau. \u201cMechanisms of cancer chemoprevention by curcumin.\u201d&nbsp;Proceedings of the National Science Council, Republic of China. Part B, Life sciences&nbsp;vol. 25,2 (2001): 59-66.<\/li><li>Plummer, S M et al. \u201cInhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK\/IKK signalling complex.\u201d&nbsp;Oncogene&nbsp;vol. 18,44 (1999): 6013-20. doi:10.1038\/sj.onc.1202980<\/li><li>Ruby, A J et al. \u201cAnti-tumour and antioxidant activity of natural curcuminoids.\u201d&nbsp;Cancer letters&nbsp;vol. 94,1 (1995): 79-83. doi:10.1016\/0304-3835(95)03827-j<\/li><li>Shoba, G et al. \u201cInfluence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.\u201d&nbsp;Planta medica&nbsp;vol. 64,4 (1998): 353-6. doi:10.1055\/s-2006-957450<\/li><li>Hosoe, Kazunori et al. \u201cStudy on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers.\u201d&nbsp;Regulatory toxicology and pharmacology : RTP&nbsp;vol. 47,1 (2007): 19-28. doi:10.1016\/j.yrtph.2006.07.001<\/li><li>Schulz, Christiane et al. \u201cComparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu Q10).\u201d&nbsp;International journal of food sciences and nutrition&nbsp;vol. 57,7-8 (2006): 546-55. doi:10.1080\/09637480601058320 )<\/li><li>\u201cHistory of Enzyme Therapy.\u201d Dr. Nicholas Gonzalez, available at: www.dr-gonzalez.com\/history_of_treatment.htm.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 14<\/strong><\/p>\n\n\n\n<ul><li>Ravnskov, Uffe, et al. \u201cLack of an Association or an Inverse Association between Low-Density-Lipoprotein Cholesterol and Mortality in the Elderly: a Systematic Review.\u201d BMJ Open, vol. 6, no. 6, 2016, doi:10.1136\/bmjopen-2015-010401.<\/li><li>\u201cClassics in arteriosclerosis research: On experimental cholesterin steatosis and its significance in the origin of some pathological processes by N. Anitschkow and S. Chalatow, translated by Mary Z. Pelias, 1913.\u201d&nbsp;Arteriosclerosis (Dallas, Tex.)&nbsp;vol. 3,2 (1983): 178-82.<\/li><li>Curtis, Ernest N. The Cholesterol Delusion. Dog Ear Pub., 2010.<\/li><li>Golomb, Beatrice A, and Marcella A Evans. \u201cStatin adverse effects : a review of the literature and evidence for a mitochondrial mechanism.\u201d&nbsp;American journal of cardiovascular drugs : drugs, devices, and other interventions&nbsp;vol. 8,6 (2008): 373-418. doi:10.2165\/0129784-200808060-00004<\/li><li>Kannel, William B. \u201cCholesterol in the Prediction of Atherosclerotic Disease.\u201d Annals of Internal Medicine, vol. 90, no. 1, 1979, p. 85., doi:10.7326\/0003-4819-90-1-85.<\/li><li>Anderson, Keaven M. \u201cCholesterol and Mortality.\u201d Jama, vol. 257, no. 16, 1987, p. 2176., doi:10.1001\/jama.1987.03390160062027.<\/li><li>Ridker, Paul M. \u201cClinical Application of C-Reactive Protein for Cardiovascular Disease Detection and Prevention.\u201d Circulation, vol. 107, no. 3, 2003, pp. 363\u2013369., doi:10.1161\/01.cir.0000053730.47739.3c.<\/li><li>Sever, Peter S et al. \u201cPrevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial\u2013Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial.\u201d&nbsp;Lancet (London, England)&nbsp;vol. 361,9364 (2003): 1149-58. doi:10.1016\/S0140-6736(03)12948-0<\/li><li>Taylor, Fiona, et al. \u201cStatins for the Primary Prevention of Cardiovascular Disease.\u201d Cochrane Database of Systematic Reviews, 2013, doi:10.1002\/14651858.cd004816.pub5.<\/li><li>Crea, Filippo, and David A Morrow. \u201cC-Reactive Protein in Cardiovascular Disease.\u201d UpToDate, 2019.<\/li><li>Hainer, Ray. \u201cThe Cholesterol-Inflammation Connection.\u201d CNN, Cable News Network, 2009, available at: edition.cnn.com\/2008\/HEALTH\/conditions\/10\/16\/healthmag.cholesterol.inflammation\/index.html#:~:text=Studies%20show%20that%20a%20substance,attack%20and%20other%20cardiovascular%20events.<\/li><li>Journal, The Wall Street. \u201cChronic Inflammation: The New Science behind America\u2019s Deadliest Diseases.\u201d Fox News, FOX News Network, 13 Nov. 2014, available at: www.foxnews.com\/health\/2012\/07\/17\/chronic-inflammation-new-science-behind-america-deadliest-diseases\/.<\/li><li>Anderson, Jeffrey L, et al. \u201cEffect of Folic Acid Fortification of Food on Homocysteine-Related Mortality.\u201d The American Journal of Medicine, vol. 116, no. 3, 2004, pp. 158\u2013164., doi:10.1016\/j.amjmed.2003.10.024.<\/li><li>Robinson, K et al. \u201cHyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease.\u201d&nbsp;Circulation&nbsp;vol. 92,10 (1995): 2825-30. doi:10.1161\/01.cir.92.10.2825<\/li><li>Maron, Bradley A., and Joseph Loscalzo. \u201cThe Treatment of Hyperhomocysteinemia.\u201d Annual Review of Medicine, vol. 60, no. 1, 2009, pp. 39\u201354., doi:10.1146\/annurev.med.60.041807.123308.<\/li><li>\u201cHistory of the Framingham Heart Study.\u201d Framingham Heart Study, available at: framinghamheartstudy.org\/fhs-about\/history\/.<\/li><li>Ravnskov, Uffe. \u201cBlood Cholesterol Has Nothing to Do with Atherosclerosis.\u201d Uffe Ravnskov, 3 Feb. 2017, available at: <a href=\"http:\/\/www.ravnskov.nu\/2015\/12\/27\/myth-2\/\">www.ravnskov.nu\/2015\/12\/27\/myth-2\/<\/a>.<\/li><li>Harvard Health Publishing. \u201cCholesterol.\u201d Harvard Health, www.health.harvard.edu\/topics\/cholesterol.<\/li><li>Hayward, Rodney A., et al. \u201cNarrative Review: Lack of Evidence for Recommended Low-Density Lipoprotein Treatment Targets: A Solvable Problem.\u201d Annals of Internal Medicine, vol. 145, no. 7, 2006, p. 520., doi:10.7326\/0003-4819-145-7-200610030-00010.<\/li><li>Al-Mallah, Mouaz H et al. \u201cLow admission LDL-cholesterol is associated with increased 3-year all-cause mortality in patients with non ST segment elevation myocardial infarction.\u201d&nbsp;Cardiology journal&nbsp;vol. 16,3 (2009): 227-33.<\/li><li>The Associated Press. \u201cCholesterol Guidelines Become a Morality Play.\u201d USA Today, Gannett Satellite Information Network, 16 Oct. 2004, available at: <a href=\"http:\/\/www.usatoday.com\/news\/health\/2004-10-16-panel-conflict-of-interest_x.htm\">www.usatoday.com\/news\/health\/2004-10-16-panel-conflict-of-interest_x.htm<\/a>.<\/li><li>Sherwood, Edward R, and Tracy Toliver-Kinsky. \u201cMechanisms of the Inflammatory Response.\u201d Best Practice &amp; Research Clinical Anaesthesiology, vol. 18, no. 3, 2004, pp. 385\u2013405., doi:10.1016\/j.bpa.2003.12.002.<\/li><li>Aguirre, Rene, and James M May. \u201cInflammation in the vascular bed: importance of vitamin C.\u201d&nbsp;Pharmacology &amp; therapeutics&nbsp;vol. 119,1 (2008): 96-103. doi:10.1016\/j.pharmthera.2008.05.002<\/li><li>Rath, Matthias, and Linus Pauling. \u201cA Unified Theory of Human Cardiovascular Disease Leading the Way to the Abolition of This Disease as a Cause for Human Mortality.\u201d Journal of Orthomolecular Medicine, vol. 7, no. 1, 1992.<\/li><li>Lynch, S M et al. \u201cAscorbic acid and atherosclerotic cardiovascular disease.\u201d&nbsp;Sub-cellular biochemistry&nbsp;vol. 25 (1996): 331-67. doi:10.1007\/978-1-4613-0325-1_17<\/li><li>Kim, Hyo Jung et al. \u201cAscorbic acid synthesis due to L-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells.\u201d&nbsp;Biochemical and biophysical research communications&nbsp;vol. 345,4 (2006): 1657-62. doi:10.1016\/j.bbrc.2006.05.090<\/li><li>Rom\u00e1n-Vi\u00f1as, Blanca et al. \u201cOverview of methods used to evaluate the adequacy of nutrient intakes for individuals and populations.\u201d&nbsp;The British journal of nutrition&nbsp;vol. 101 Suppl 2 (2009): S6-11. doi:10.1017\/S0007114509990535<\/li><li>\u201cLow LDL Cholesterol Is Related to Cancer Risk.\u201d ScienceDaily, ScienceDaily, 26 Mar. 2012, available at: www.sciencedaily.com\/releases\/2012\/03\/120326113713.htm.<\/li><li>Alsheikh-Ali, Alawi A et al. \u201cEffect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials.\u201d&nbsp;Journal of the American College of Cardiology&nbsp;vol. 50,5 (2007): 409-18. doi:10.1016\/j.jacc.2007.02.073<\/li><li>Geleijnse, Johanna M et al. \u201cDietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study.\u201d&nbsp;The Journal of nutrition&nbsp;vol. 134,11 (2004): 3100-5. doi:10.1093\/jn\/134.11.3100<\/li><\/ul>\n\n\n\n<p><strong>Chapter 15<\/strong><\/p>\n\n\n\n<ul><li>Rosedale, Ron, and Carol Colman. The Rosedale Diet. 1st ed., William Morrow, 2004.<\/li><li>\u201cInsulin Resistance &amp; Prediabetes.\u201d National Institute of Diabetes and Digestive and Kidney Diseases, U.S. Department of Health and Human Services, 1 May 2018, available at: www.niddk.nih.gov\/health-information\/diabetes\/overview\/what-is-diabetes\/prediabetes-insulin-resistance.<\/li><li>Olatunbosun, Samuel T. \u201cInsulin Resistance.\u201d Edited by George T Griffing, Practice Essentials, Pathophysiology, Etiology, 30 Mar. 2020, available at: emedicine.medscape.com\/article\/122501-overview.<\/li><li>Reaven, G M. \u201cInsulin resistance, the insulin resistance syndrome, and cardiovascular disease.\u201d&nbsp;Panminerva medica&nbsp;vol. 47,4 (2005): 201-10.<\/li><li>Basciano, Heather, et al. \u201cFructose, Insulin Resistance, and Metabolic Dyslipidemia.\u201d Nutrition &amp; Metabolism, vol. 2, no. 1, 2005, p. 5., doi:10.1186\/1743-7075-2-5.<\/li><li>Shapiro, Alexandra et al. \u201cPrevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat content.\u201d&nbsp;The British journal of nutrition&nbsp;vol. 106,3 (2011): 390-7. doi:10.1017\/S000711451100033X<\/li><li>Shapiro, Alexandra et al. \u201cFructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding.\u201d&nbsp;American journal of physiology. Regulatory, integrative and comparative physiology&nbsp;vol. 295,5 (2008): R1370-5. doi:10.1152\/ajpregu.00195.2008<\/li><li>Scarpace, Philip J, and Yi Zhang. \u201cLeptin resistance: a prediposing factor for diet-induced obesity.\u201d&nbsp;American journal of physiology. Regulatory, integrative and comparative physiology&nbsp;vol. 296,3 (2009): R493-500. doi:10.1152\/ajpregu.90669.2008<\/li><li>Hill, Jennifer W et al. \u201cDirect insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.\u201d&nbsp;Cell metabolism&nbsp;vol. 11,4 (2010): 286-97. doi:10.1016\/j.cmet.2010.03.002<\/li><li>Choi, Hyung Jin, et al. \u201cVitamin K2 Supplementation Improves Insulin Sensitivity via Osteocalcin Metabolism: A Placebo-Controlled Trial.\u201d Diabetes Care, vol. 34, no. 9, 2011, doi:10.2337\/dc11-0551.<\/li><li>Beulens, Joline W J et al. \u201cDietary phylloquinone and menaquinones intakes and risk of type 2 diabetes.\u201d&nbsp;Diabetes care&nbsp;vol. 33,8 (2010): 1699-705. doi:10.2337\/dc09-2302<\/li><li>Khan, Alam et al. \u201cCinnamon improves glucose and lipids of people with type 2 diabetes.\u201d&nbsp;Diabetes care&nbsp;vol. 26,12 (2003): 3215-8. doi:10.2337\/diacare.26.12.3215<\/li><li>Akilen, R et al. \u201cGlycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial.\u201d&nbsp;Diabetic medicine : a journal of the British Diabetic Association&nbsp;vol. 27,10 (2010): 1159-67. doi:10.1111\/j.1464-5491.2010.03079.x<\/li><li>Sheriff, Natasja. \u201cSelenium Linked to Lower Diabetes Risk.\u201d Reuters, Thomson Reuters, 8 June 2012, available at: www.reuters.com\/article\/2012\/06\/08\/us-selenium-diabetes-risk-idUSBRE85718U20120608.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 16<\/strong><\/p>\n\n\n\n<ul><li>Mosley, Dr Michael. \u201cThe 5:2 Diet: Can It Help You Lose Weight and Live Longer?\u201d The Telegraph, Telegraph Media Group, 16 Aug. 2012, available at: www.telegraph.co.uk\/lifestyle\/9480451\/The-52-diet-can-it-help-you-lose-weight-and-live-longer.html#.<\/li><li>Anderson, Rozalyn M et al. \u201cCaloric restriction and aging: studies in mice and monkeys.\u201d&nbsp;Toxicologic pathology&nbsp;vol. 37,1 (2009): 47-51. doi:10.1177\/0192623308329476<\/li><li>Lane, M A et al. \u201cCaloric restriction in primates.\u201d&nbsp;Annals of the New York Academy of Sciences&nbsp;vol. 928 (2001): 287-95. doi:10.1111\/j.1749-6632.2001.tb05658.x<\/li><li>Ribari\u010d, Samo. \u201cDiet and aging.\u201d&nbsp;Oxidative medicine and cellular longevity&nbsp;vol. 2012 (2012): 741468. doi:10.1155\/2012\/741468<\/li><li>Turner, Christopher. \u201cThe Calorie Restriction Dieters.\u201d The Telegraph, Telegraph Media Group, 25 July 2010, available at: www.telegraph.co.uk\/news\/health\/7898775\/The-Calorie-Restriction-dieters.html.<\/li><li>Varady, Krista A, and Marc K Hellerstein. \u201cAlternate-day fasting and chronic disease prevention: a review of human and animal trials.\u201d&nbsp;The American journal of clinical nutrition&nbsp;vol. 86,1 (2007): 7-13. doi:10.1093\/ajcn\/86.1.7<\/li><li>Bhutani, Surabhi et al. \u201cImprovements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations.\u201d&nbsp;Obesity (Silver Spring, Md.)&nbsp;vol. 18,11 (2010): 2152-9. doi:10.1038\/oby.2010.54<\/li><li>Clemmons, David R. \u201cThe Relative Roles of Growth Hormone and IGF-1 in Controlling Insulin Sensitivity.\u201d Journal of Clinical Investigation, vol. 113, no. 1, 2004, pp. 25\u201327., doi:10.1172\/jci20660.<\/li><li>Zhou, Y et al. \u201cA mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor\/binding protein gene (the Laron mouse).\u201d&nbsp;Proceedings of the National Academy of Sciences of the United States of America&nbsp;vol. 94,24 (1997): 13215-20. doi:10.1073\/pnas.94.24.13215<\/li><li>Guevara-Aguirre, Jaime et al. \u201cGrowth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.\u201d&nbsp;Science translational medicine&nbsp;vol. 3,70 (2011): 70ra13. doi:10.1126\/scitranslmed.3001845<\/li><li>Wade, Nicholas. \u201cEcuadorean Villagers May Hold Secret to Longevity.\u201d The New York Times, The New York Times, 16 Feb. 2011, available at: www.nytimes.com\/2011\/02\/17\/science\/17longevity.html.<\/li><li>Bai, Nina. \u201cDefective Growth Gene in Rare Dwarfism Disorder Stunts Cancer and Diabetes.\u201d Scientific American, Scientific American, 17 Feb. 2011, available at: www.scientificamerican.com\/article\/defective-growth-gene-in-dwarfism\/.<\/li><li>Rosedale, Ron. \u201cInsulin Resistance: The Real Culprit.\u201d<\/li><li>Lee, Changhan et al. \u201cFasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy.\u201d&nbsp;Science translational medicine&nbsp;vol. 4,124 (2012): 124ra27. doi:10.1126\/scitranslmed.3003293<\/li><li>Lee, C, and V D Longo. \u201cFasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients.\u201d&nbsp;Oncogene&nbsp;vol. 30,30 (2011): 3305-16. doi:10.1038\/onc.2011.91<\/li><li>Park, Alice. \u201cDwarfism May Hold Key to Fighting Cancer and Diabetes, and Living a Long Life.\u201d TIME, 17 Feb. 2011, available at: healthland.time.com\/2011\/02\/17\/dwarfism-may-hold-key-to-fighting-cancer-and-diabetes-and-living-a-long-life\/.<\/li><li>\u201cWorld Hunger, Poverty Facts, Statistics 2018.\u201d World Hunger News, 29 Nov. 2018, available at: www.worldhunger.org\/world-hunger-and-poverty-facts-and-statistics\/.<\/li><li>Weston Price&nbsp;Nutrition and Physical Degeneration&nbsp;1938<\/li><li>Williams&nbsp;Roger Biochemical Individuality&nbsp;1998<\/li><\/ul>\n\n\n\n<p><strong>Chapter 17<\/strong><\/p>\n\n\n\n<ul><li>Leitch, I. (1942)&nbsp;The evolution of dietary standards.&nbsp;Nutr.&nbsp;Abs. Rev. 11:509-521<\/li><li>Murphy, Suzanne P, et al. \u201cHistory of Nutrition: The Long Road Leading to the Dietary Reference Intakes for the United States and Canada.\u201d Advances in Nutrition, vol. 7, no. 1, 2016, pp. 157\u2013168., doi:10.3945\/an.115.010322.<\/li><li>Heaney, Robert P. \u201cVitamin D: Criteria for Safety and Efficacy.\u201d Nutrition Reviews, vol. 66, 2008, doi:10.1111\/j.1753-4887.2008.00102.x.<\/li><li><a href=\"https:\/\/www.drtsoukalas.com\/uploads\/file\/Am%20J%20Clin%20Nutr-2007-Hathcock-6-18.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Risk assessment for vitamin D. John N Hathcock, Andrew Shao,<\/a>&nbsp;<a href=\"https:\/\/www.drtsoukalas.com\/uploads\/file\/Am%20J%20Clin%20Nutr-2007-Hathcock-6-18.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Reinhold Vieth,<\/a>&nbsp;<a href=\"https:\/\/www.drtsoukalas.com\/uploads\/file\/Am%20J%20Clin%20Nutr-2007-Hathcock-6-18.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">and Robert Heaney. Am J Clin Nutr 2007;85:6\u201318<\/a><\/li><li><a href=\"https:\/\/www.mayoclinicproceedings.org\/article\/S0025-6196(15)00244-X\/abstract#intraref0010\" target=\"_blank\" rel=\"noreferrer noopener\">Vitamin D Is Not as Toxic as Was Once Thought: A Historical and an Up-to-Date Perspective Michael F. Holick, PhD, MD<\/a>&nbsp;Mayo Clinic Proceedings. DOI: https:\/\/doi.org\/10.1016\/j.mayocp.2015.03.015<\/li><li>News Service, Orthomolecular Medicine. \u201cNo Deaths From Vitamins or Minerals.\u201d No Deaths From Vitamins or Minerals, 14 Oct. 2009, available at: www.orthomolecular.org\/resources\/omns\/v05n04.shtml.<\/li><li>\u201cVitamins and Minerals.\u201d The Nutrition Source, 25 Mar. 2020, available at: <a href=\"http:\/\/www.hsph.harvard.edu\/nutritionsource\/vitamins\/\">www.hsph.harvard.edu\/nutritionsource\/vitamins\/<\/a>.<\/li><li>Lazarou, Jason, et al. \u201cIncidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-Analysis of Prospective Studies.\u201d Survey of Anesthesiology, vol. 43, no. 1, 1999, pp. 53\u201354., doi:10.1097\/00132586-199902000-00059.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 18<\/strong><\/p>\n\n\n\n<ul><li>Nguyen, D.t., et al. \u201cThe Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration.\u201d Biomaterials for Treating Skin Loss, 2009, pp. 25\u201357., doi:10.1533\/9781845695545.1.25.<\/li><li>Nguen, D. T., et al. \u201cThe Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration.\u201d Biomaterials for Treating Skin Loss, by Dennis Orgill and D. P. Orgill, Woodhead Publishing, 2009, pp. 25\u201353.<\/li><li>Seematter G, Dirlewanger M, Rey V, Schneiter P, Tappy L. Metabolic effects of mental stress during over- and underfeeding in healthy women.&nbsp;Obes Res. 2002;10(1):49\u201055. doi:10.1038\/oby.2002.7<\/li><li>Selye, Hans. The Stress of Life. McGraw-Hill, 1984.<\/li><li>Ghiadoni, L et al. \u201cMental stress induces transient endothelial dysfunction in humans.\u201d&nbsp;Circulation&nbsp;vol. 102,20 (2000): 2473-8. doi:10.1161\/01.cir.102.20.2473<\/li><li>Sloan, R.p., et al. \u201cEffect of Mental Stress throughout the Day on Cardiac Autonomic Control.\u201d Biological Psychology, vol. 37, no. 2, 1994, pp. 89\u201399., doi:10.1016\/0301-0511(94)90024-8.<\/li><li>Cohen, S., et al. \u201cChronic Stress, Glucocorticoid Receptor Resistance, Inflammation, and Disease Risk.\u201d Proceedings of the National Academy of Sciences, vol. 109, no. 16, 2012, pp. 5995\u20135999., doi:10.1073\/pnas.1118355109.<\/li><\/ul>\n\n\n\n<p><strong>Chapter 19<\/strong><\/p>\n\n\n\n<ul><li>Savitz, Eric. \u201cThe Untapped Power Of Smiling.\u201d Forbes, Forbes Magazine, 10 Aug. 2011, available at: www.forbes.com\/sites\/ericsavitz\/2011\/03\/22\/the-untapped-power-of-smiling\/#65b802d37a67.<\/li><li>Harvard Health Publishing. \u201cThe Happiness-Health Connection.\u201d Harvard Health, available at: www.health.harvard.edu\/healthbeat\/the-happiness-health-connection.<\/li><li>Abel, Ernest L., and Michael L. Kruger. \u201cSmile Intensity in Photographs Predicts Longevity.\u201d Psychological Science, vol. 21, no. 4, 2010, pp. 542\u2013544., doi:10.1177\/0956797610363775.<\/li><li>Moskowitz, Clara. \u201cSmiles Predict Marriage Success.\u201d LiveScience, Purch, 14 Apr. 2009, available at: www.livescience.com\/3503-smiles-predict-marriage-success.html.<\/li><li>\u201cHealth | Scanner Shows Unborn Babies Smile.\u201d BBC News, BBC, 13 Sept. 2003, available at: news.bbc.co.uk\/2\/hi\/health\/3105580.stm.<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Il libro &#8220;Come vivere 150 anni&#8221; del Dr. Tsoukalas fa riferimento a innumerevoli ricerche in ambito scientifico e medico. Sarebbe stato impossibile includere nel libro tutti i riferimenti bibliografici a cui esso attinge. In questa pagina daremo alcuni approfondimenti sugli argomenti toccati nel volume e forniremo la vasta bibliografia associata. 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